Press Release

Press Release

Singular Genomics Reports Recent Highlights and Fourth Quarter and Full Year 2022 Financial Results

Mar 02, 2023

SAN DIEGO, March 02, 2023 (GLOBE NEWSWIRE) -- Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the fourth quarter and full year ended December 31, 2022.

“2022 was a pivotal year for Singular Genomics. It was a year in which we achieved important milestones, overcame challenges, and ultimately ended on a strong note with five G4 systems in market. Most importantly, the business is set up for success with the right team, the right product, and the right opportunity. I am tremendously proud of the entire Singular team," said Drew Spaventa, Chairman and Chief Executive Officer of Singular Genomics. “In 2023, we will remain focused on customer success across a growing installed base, commercial and operational execution, and advancing our innovation pipeline.”

Fourth Quarter and Recent Highlights

  • Generated the company’s first quarter of revenue of $765 thousand for the fourth quarter of 2022
  • Shipped four G4 systems to new customers in the fourth quarter of 2022, bringing our total commercial systems shipped to five as of the end of 2022
  • Launched Max Read kits for single cell sequencing, with an expected ship date in the second quarter, which boosts the potential output of the G4 to 800 million reads per flow cell, or a market-leading 3.2 billion reads per run on a benchtop system
  • Joined the 10x Genomics Compatible Partner Program, demonstrating compatibility of the G4 sequencing platform with 10x Genomics’ single cell applications
  • Increased the quality specifications for the G4 to 80%–90% Q30
  • Raised the throughput range of the F2 and F3 flow cells to up to 250 million and up to 450 million reads, respectively
  • Produced 14 new data sets, 11 with industry-leading genomics partners, showcasing high accuracy of the G4 across many diverse applications

Fourth Quarter 2022 Financial Results

Revenue for the fourth quarter of 2022 was $765 thousand, marking the first revenue generating quarter. Revenue was comprised predominantly of the revenue recognized on three instrument placements during the quarter. Operating expenses for the fourth quarter of 2022 totaled $22.5 million, compared to $19.7 million for the fourth quarter of 2021. Operating expenses included non-cash stock-based compensation of $3.1 million for the fourth quarter of 2022 and $2.9 million for the fourth quarter of 2021. The year-over-year increase in operating expenses was driven primarily by scaling headcount and infrastructure to support our growth, including the G4 launch, product pipeline and R&D roadmap.

Net loss for the fourth quarter of 2022 was $21.1 million, or a loss of $0.29 per common share, compared to $19.8 million, or a loss of $0.27 per common share, in the fourth quarter of 2021.

Full Year 2022 Financial Results

Revenue for the full year of 2022 was $765 thousand. Revenue was comprised predominantly of the revenue recognized on three instrument placements during the fourth quarter. Operating expenses for 2022 totaled $93.5 million compared to $61.3 million in the prior year period. Operating expenses included non-cash stock-based compensation expense of $13.7 million in 2022 and $9.2 million in 2021. The year-over-year increase in total operating expenses was driven primarily by scaling headcount and infrastructure to support our growth, including the G4 launch, product pipeline and R&D roadmap, and the costs associated with being a public company.

Net loss for 2022 was $90.9 million, or a loss of $1.28 per common share, compared to $98.8 million, or a loss of $2.10 per common share, in 2021.

Cash, cash equivalents and short-term investments, excluding restricted cash, as of December 31, 2022 totaled $244.6 million.

Webcast and Conference Call Details

Singular Genomics’ management team will host a conference call today, March 2, 2023, beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time. Investors interested in listening to the conference call may do so by accessing a live and archived webcast of the event at, in the Presentations & Events section.

About Singular Genomics Systems, Inc.

Singular Genomics is a life science technology company that develops next-generation sequencing and multiomics technologies. The commercially available G4 Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In development, the PX system leverages Singular’s proprietary sequencing technology, applying it as an in-situ readout to look at RNA and proteins in single cells and tissue. With these products, Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine. Visit for more information.

Forward-Looking Statements

Certain statements contained in this press release, other than historical information, constitute forward-looking statements within the meaning of the federal securities laws. Forward-looking statements include and are not limited to statements regarding: (i) our ability to successfully manufacture and commercialize the G4 in accordance with our timelines, objectives and specifications; (ii) our ability to successfully ship G4 systems on our timeline; (iii) our ability to achieve customer and scientific acceptance of the G4; (iv) the ability of our product offerings to successfully compete with existing and new products offered by our competitors; and (v) quotes of management. Any such forward-looking statements are based on our management’s current expectations and are subject to risks and uncertainties that could cause our actual future results to differ materially from our management’s current expectations or those implied by our forward-looking statements. These risks and uncertainties include and are not limited to the following: (i) we have incurred significant losses since inception, we expect to incur significant losses in the future and we may not be able to generate sufficient revenue to achieve and maintain profitability; (ii) we have very little history manufacturing and commercializing our products or technology; (iii) the life sciences technology market is highly competitive, and if we fail to compete effectively, our business and operating results will suffer; (iv) if we are sued for infringing, misappropriating or otherwise violating intellectual property rights of third parties, such litigation could be costly and time consuming and could prevent or delay us from developing or commercializing our products; (v) if our products fail to achieve early customer and scientific acceptance, we may not be able to achieve broader market acceptance for our products, and our revenues and prospects may be harmed; (vi) we expect to be highly dependent upon revenue generated from the sale of the G4 and planned PX, and any delay or failure by us to successfully manufacture and commercialize the G4 and planned PX could have a substantial adverse effect on our business and results of operations; and (vii) the COVID-19 pandemic, efforts to reduce its spread and recent macroeconomic challenges have adversely impacted, and may materially and adversely impact, our business, operations and product manufacturing and commercialization objectives. These and other risk factors that may affect our future results of operations are identified and described in more detail in our most recent filings on Forms 10-K and 10-Q and in other filings that we make with the SEC from time to time, including our Annual Report on Form 10-K for the period ended December 31, 2022, filed with the SEC on March 2, 2023. Accordingly, you should not rely on forward-looking statements as predictions of future events or our future performance. Except as required by law, we undertake no obligation to update publicly or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

Investor Contact

Matt Clawson

Media Contact

Dan Budwick, 1AB

Singular Genomics Systems, Inc.
Statements of Operations
(In thousands, except share and per share amounts)

 Three Months Ended December 31,  Year Ended December 31, 
 2022  2021  2022  2021 
Revenue$765  $-  $765  $- 
Cost of revenue 789   -   789   - 
Gross margin (24)  -   (24)  - 
Operating expenses:           
Research and development 10,760   9,455   46,199   32,655 
Selling, general and administrative 11,746   10,218   47,264   28,624 
Total operating expenses 22,506   19,673   93,463   61,279 
Loss from operations (22,530)  (19,673)  (93,487)  (61,279)
Other income (expense):           
Interest expense (243)  (192)  (763)  (846)
Change in fair value of convertible promissory notes -   -   -   (35,199)
Change in fair value of warrant liability -   -   -   (2,180)
Interest and other income 1,672   106   3,371   733 
Total other income (expense) 1,429   (86)  2,608   (37,492)
Net loss$(21,101) $(19,759) $(90,879) $(98,771)
Net loss per share:           
Basic and diluted net loss per share$(0.29) $(0.27) $(1.28) $(2.10)
Weighted-average shares used to compute basic and diluted net loss per share 71,584,976   72,162,679   71,148,076   47,023,048 

Singular Genomics Systems, Inc.
Balance Sheets
(In thousands, except share and par value amounts)

  December 31, 
  2022  2021 
Current assets:      
Cash and cash equivalents $74,266  $201,049 
Short-term investments  170,310   138,174 
Accounts receivable  913   - 
Inventory  18,221   3,011 
Prepaid expenses and other current assets  4,722   5,526 
Total current assets  268,432   347,760 
Right-of-use lease assets  45,896   - 
Property and equipment, net  10,784   6,072 
Restricted cash  1,711   687 
Other noncurrent assets  1,152   1,129 
Total assets $327,975  $355,648 
Liabilities and Stockholders’ Equity      
Current liabilities:      
Accounts payable $3,099  $2,348 
Accrued expenses  4,583   4,278 
Lease liabilities, current  6,323   - 
Other current liabilities  113   118 
Total current liabilities  14,118   6,744 
Lease liabilities, noncurrent  42,456   - 
Long-term debt, net of issuance costs  10,065   9,904 
Other noncurrent liabilities  1,015   2,827 
Total liabilities  67,654   19,475 
Commitments and contingencies      
Stockholders’ equity:      
Series A common stock equivalent convertible preferred stock, $0.0001 par value; 7,000 shares authorized, 2,500 and no shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively  -   - 
Common stock, $0.0001 par value; 400,000,000 shares authorized, 71,854,688 and 72,438,742 shares outstanding at December 31, 2022 and December 31, 2021, respectively  7   7 
Additional paid-in capital  503,926   488,200 
Accumulated other comprehensive loss  (837)  (138)
Accumulated deficit  (242,775)  (151,896)
Total stockholders’ equity  260,321   336,173 
Total liabilities and stockholders’ equity $327,975  $355,648